Hydroxyamine hydrochloride → 6-(2-Dimethylamino-1,1-dimethyl-ethoxy)-pyridazin-3-ylamine

Participants

Reaction Steps

In a 10 mL pear shape flask was added 6-(1-(dimethylamino)-2-methylpropan-2-yloxy)-N-(diphenylmethylene)pyridazin-3-amine (200 mg, 534 μmol, Eq: 1.00) and MeOH (5.34 ml). To the mixture was added hydroxylamine hydrochloride (66.8 mg, 961 μmol, Eq: 1.8) and sodium acetate (105 mg, 1.28 mmol, Eq: 2.4). The mixture was stirred at room temperature for 25 min. The reaction mixture was absorbed on to silica and purified by LC chromatography eluting with 0-5% (10% NH4OH in MeOH) in 1/1 EtOAc/Hexane to afford 110 mg (98%) of the title compound.

Provenance & Evidence