HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-chlorobenzoic acid → 4,6-Dichloro-2-(2-fluorophenyl)-3-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-chlorobenzoic acid | HCID 12476 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-(2-Fluorophenyl)propan-1-one | HCID 579399 | — |
| Product | 4,6-Dichloro-2-(2-fluorophenyl)-3-methylquinoline | HCID 59631327 | — |
Reaction Steps
Prepared according to Procedure J using 2-amino-5-chlorobenzoic acid (1.5 equiv.) and 1-(2-fluorophenyl)propan-1-one (1 equiv.) in phosphorous oxychloride to afford 4,6-dichloro-2-(2-fluorophenyl)-3-methylquinoline upon purification by chromatography on silica gel. Mass Spectrum (ESI) m/e=306.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-dfb14b945b9645f59ddd255130b5b720 |
| Source note | uspto-grants-2015_01 |