反应详情

Prepared according to general Procedure F using 2,4-dichloro-6-fluoro-3-methylquinoline (300 mg, 1.3 mmol), 3-pyridylboronic acid (160 mg, 1.3 mmol), tetrakis(triphenylphosphine)palladium(0), sodium carbonate (242 mg, 2.28 mmol) in toluene:water (5 mL:2 mL) and heating at 130° C. overnight. After purification 4-chloro-6-fluoro-3-methyl-2-(pyridin-3-yl)quinoline was obtained as a white solid.

1. customPrepared
2. customAfter purification 4-chloro-6-fluoro-3-methyl-2-(pyridin-3-yl)quinoline
3. customwas obtained as a white solid