huagongshe.com
HRID1431241

反应详情

EQUATION

反应方程式

HRID 1431241 的结构方程式

REACTANTS

反应物

2
结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1ccccn1
HCID607784

2-(Tributylstannyl)pyridine

C17H31NSn

结构：Cc1c(Cl)nc2ccc(F)cc2c1Cl
HCID59631220

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(-c2ccccn2)nc2ccc(F)cc2c1Cl
HCID59631354

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度
110 °C

PROCEDURE

实验过程

Prepared according to general Procedure E using 2,4-dichloro-6-fluoro-3-methylquinoline (250 mg, 1.1 mmol), 2-(tributylstannyl)pyridine (400 mg, 1.1 mmol), tetrakis(triphenylphosphine)palladium(0) (63 mg, 0.05 mmol) in toluene (5 mL) and heating at 110° C. overnight. After purification 4-chloro-6-fluoro-3-methyl-2-(pyridin-2-yl)quinoline was obtained as a white solid.

WORKUP

后处理

  1. customPrepared
  2. customAfter purification 4-chloro-6-fluoro-3-methyl-2-(pyridin-2-yl)quinoline
  3. customwas obtained as a white solid