反应详情

Prepared according to general Procedure K using 4-chloro-7-fluoro-2-(2-fluorophenyl)-3-methylquinoline (100 mg, 0.34 mmol), 2,5-dimorpholinopyridin-3-amine (91 mg, 0.34 mmol) and a 4.0M solution of HCl in dioxane (0.017 mL, 0.069 mmol) in MeOH (1.0 mL) and heating in the microwave for 2 h at 150° C. After purification N-(2,5-di-4-morpholinyl-3-pyridinyl)-7-fluoro-2-(2-fluorophenyl)-3-methyl-4-quinolinamine was obtained as a yellow film. 1H NMR (500 MHz, chloroform-d) δ ppm δ ppm 7.85 (1H, br. s.), 7.81 (1H, dd, J=9.9, 2.6 Hz), 7.58-7.65 (2H, m), 7.44-7.51 (1H, m), 7.30-7.37 (2H, m), 7.20 (1H, t, J=9.2 Hz), 6.85 (1H, br. s.), 6.27 (1H, br. s.), 3.94 (4H, t, J=4.6 Hz), 3.71-3.80 (4H, m), 3.22 (4H, br. s.), 2.98 (4H, br. s.), 2.18 (3H, s). Mass Spectrum (ESI) m/e=518.2 (M+1).

1. customPrepared
2. customAfter purification N-(2,5-di-4-morpholinyl-3-pyridinyl)-7-fluoro-2-(2-fluorophenyl)-3-methyl-4-quinolinamine
3. customwas obtained as a yellow film