反应详情

To a stirred solution of 4-chloro-2-nitrobenzonitrile (2.0 g, 11 mmol) in THF (40 mL) was added morpholine (1.0 g, 11 mmol). The reaction was heated at reflux overnight. After this time the reaction was cooled to rt and then it was partitioned between EtOAc (150 mL) and NaHCO3 (50 mL, satd aq. solution). The separated organic layer was dried over magnesium sulfate, filtered and evaporated in vacuo. Column chromatography (hexanes:EtOAc, 1:0 to 1:1) gave 4-morpholino-2-nitrobenzonitrile.

1. temperatureThe reaction was heated
2. temperatureat reflux overnight
3. customit was partitioned between EtOAc (150 mL) and NaHCO3 (50 mL, satd aq. solution)
4. dry with materialThe separated organic layer was dried over magnesium sulfate
5. filtrationfiltered
6. customevaporated in vacuo