HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Morpholino-2-nitrobenzonitrile → 2-Amino-4-(4-morpholinyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Morpholino-2-nitrobenzonitrile | HCID 13499265 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-4-(4-morpholinyl)benzonitrile | HCID 13499283 | — |
Reaction Steps
A solution of 4-morpholino-2-nitrobenzonitrile (300 mg, 0.24 mmol) in MeOH (140 mL) was reduced using a continuos flow hydrogenation reactor (flow rate: 1 mL/min, 10% mol Pd/C, temperature 40° C., H2 pressure: 10 atm) to give 2-amino-4-morpholinobenzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f8028d6e3d29430db727166dde4e97db |
| Source note | uspto-grants-2015_01 |