HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Nitro-4-(pyridin-3-yl)phenyl)morpholine → 2-Morpholino-5-(pyridin-3-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Nitro-4-(pyridin-3-yl)phenyl)morpholine | HCID 59631210 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Morpholino-5-(pyridin-3-yl)aniline | HCID 59631095 | — |
Reaction Steps
A solution of 4-(2-nitro-4-(pyridin-3-yl)phenyl)morpholine (300 mg, 0.24 mmol) in MeOH (140 mL) was reduced using a continuous flow hydrogenation reactor (flow rate: 1 mL/min, 10% mol Pd/C, temperature 40° C., H2 pressure: 10 bar) to give 2-morpholino-5-(pyridin-3-yl)aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-e4945ef787b94253afe64ba564528e56 |
| Source note | uspto-grants-2015_01 |