反应详情

Prepared according to general Procedure K using 4-chloro-2-(2-fluorophenyl)-3-methylquinoline (64 mg, 0.23 mmol), 2-morpholino-5-(pyridin-3-yl)aniline (60 mg, 0.23 mmol) and a 4.0M solution of HCl in dioxane (0.06 mL, 0.23 mmol) in NMP (1.0 mL) and heating in the microwave for 2 h at 150° C. After purification 2-(2-fluorophenyl)-3-methyl-N-(2-(4-morpholinyl)-5-(3-pyridinyl)phenyl)-4-quinolinamine was obtained. 1H NMR (400 MHz, chloroform-d) δ ppm 8.49 (1H, dd, J=4.7, 1.6 Hz), 8.19 (1H, d, J=8.2 Hz), 7.92 (1H, d, J=8.2 Hz), 7.59-7.76 (4H, m), 7.54 (1H, d, J=7.4 Hz), 7.47 (1H, d, J=8.2 Hz), 7.31-7.36 (1H, m), 7.10-7.24 (4H, m), 6.65 (1H, br. s.), 3.97 (4H, t, J=4.7 Hz), 3.09-3.30 (4H, m), 2.26 (3H, d, J=2.3 Hz). Mass Spectrum (ESI) m/e=491.0 (M+1).

1. customPrepared
2. customAfter purification 2-(2-fluorophenyl)-3-methyl-N-(2-(4-morpholinyl)-5-(3-pyridinyl)phenyl)-4-quinolinamine
3. customwas obtained