HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Nitro-5-thiomorpholinopyridin-2-yl)morpholine → 2-(4-morpholinyl)-5-(4-thiomorpholinyl)-3-Pyridinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Nitro-5-thiomorpholinopyridin-2-yl)morpholine | HCID 59631280 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-morpholinyl)-5-(4-thiomorpholinyl)-3-Pyridinamine | HCID 59631371 | — |
Reaction Steps
A solution of 4-(3-nitro-5-thiomorpholinopyridin-2-yl)morpholine (140 mg, 0.45 mmol) in MeOH (100 mL) was reduced using a continuous flow hydrogenation reactor (flow rate: 1 mL/min, 10% mol Pd/C, temperature 35° C., H2 pressure: 10 bar) to give 2-morpholino-5-thiomorpholinopyridin-3-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-93876271b0804e1f84bb077ae34a5db0 |
| Source note | uspto-grants-2015_01 |