HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178421969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline | HCID 59631075 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178421969 | HCID 178421969 | — |
Reaction Steps
4-Chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline (200 mg, 0.73 mmol) in NMP (2 mL) and water (0.26 mL, 14.7 mmol) was heated in the microwave at 150° C. for 4 h. After this EtOAc (10 mL) was added. The resulting precipitate was filtered to give 7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ol. Mass Spectrum (ESI) m/e=255.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-74451572b19349dab1bf046f9345b294 |
| Source note | uspto-grants-2015_01 |