Hydrochloric Acid → HCID 59631530, compound

Participants

Reaction Steps

Prepared according to Procedure K, Method 1 using 4-chloro-3-methyl-2-phenylquinoline (150 mg, 591 μmol), 2,5-dimorpholinobenzenamine (156 mg, 591 μmol) and 4N hydrochloric acid solution in dioxane (0.15 mL, 591 μmol) in MeOH (3.00 mL) to afford product as a colorless solid after purification by chromatography on silica gel eluting with MeOH gradient in DCM. 1H NMR (400 MHz, chloroform-d) δ ppm 8.18 (1H, d, J=8.2 Hz), 7.90 (1H, dd, J=8.6, 1.2 Hz), 7.69 (1H, td, J=7.6, 1.2 Hz), 7.59-7.66 (2H, m), 7.41-7.57 (4H, m), 7.23 (1H, s), 7.12 (1H, d, J=8.6 Hz), 6.44 (1H, dd, J=8.6, 2.7 Hz), 6.04 (1H, d, J=2.7 Hz), 3.88-4.01 (4H, m), 3.69-3.80 (4H, m), 3.02-3.16 (4H, m), 2.88-3.00 (4H, m), 2.32 (3H, s). Mass Spectrum (ESI) m/e=481.3 (M+1).

Provenance & Evidence