HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 4-Chloro-5-fluoro-2-(2-fluorophenyl)-3-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Amino-6-fluorobenzoic acid | HCID 521142 | — |
| Reactant | 1-(2-Fluorophenyl)propan-1-one | HCID 579399 | — |
| Product | 4-Chloro-5-fluoro-2-(2-fluorophenyl)-3-methylquinoline | HCID 59631445 | — |
Reaction Steps
Prepared according to Procedure J using 1-(2-fluorophenyl)propan-1-one and 2-amino-6-fluorobenzoic acid in phosphorous oxychloride to afford a colorless solid upon purification by chromatography on silica gel. Mass Spectrum (ESI) m/e=290.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-2307e20cd17b4375b22da575d0c15d71 |
| Source note | uspto-grants-2015_01 |