Hydrochloric Acid → HCID 59631215, compound

Participants

Reaction Steps

Prepared according to Procedure K, Method 2 using 4-chloro-3-methyl-2-(pyridin-2-yl)quinoline (77 mg, 302 μmol), 2,5-dimorpholinobenzenamine (80 mg, 302 μmol) and 4N hydrochloric acid solution in dioxane (7.6 μL, 30 μmol) in NMP (1 mL) to afford product as a colorless solid upon purification by reversed phase HPLC. 1H NMR (400 MHz, chloroform-d) δ ppm 8.58-8.72 (1H, m), 8.13 (1H, d, J=8.6 Hz), 7.74-7.90 (3H, m), 7.54-7.68 (1H, m), 7.39 (1H, td, J=7.6, 1.2 Hz), 7.25-7.35 (1H, m), 7.15 (1H, s), 7.02 (1H, d, J=8.6 Hz), 6.35 (1H, dd, J=8.6, 2.7 Hz), 5.95 (1H, d, J=2.7 Hz), 3.74-3.93 (4H, m), 3.52-3.72 (4H, m), 2.99 (4H, d, J=3.9 Hz), 2.72-2.89 (4H, m), 2.31 (3H, s). Mass Spectrum (ESI) m/e=482.2 (M+1).

Provenance & Evidence