HRID1431301

反应详情

EQUATION

反应方程式

HRID 1431301 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

PROCEDURE

实验过程

Prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline (39.8 mg, 0.137 mmol) and 2,5-dimorpholinoaniline in toluene to give N-(2,5-di-4-morpholinylphenyl)-5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (CDCl3) δ ppm 8.71 (1H, d, J=4.7 Hz), 8.15 (1H, d, J=10.2 Hz), 7.82-7.97 (2H, m), 7.64 (1H, d, J=9.4 Hz), 7.38 (1H, ddd, J=6.7, 4.7, 2.3 Hz), 7.10 (1H, d, J=8.6 Hz), 6.99 (1H, ddd, J=13.3, 8.6, 2.7 Hz), 6.48 (1H, dd, J=8.4, 2.5 Hz), 6.22 (1H, d, J=2.3 Hz), 3.90 (4H, t, J=4.3 Hz), 3.76-3.85 (4H, m), 3.05-3.19 (4H, m), 2.92 (4H, br. s.), 2.22 (3H, s). Mass Spectrum (ESI) m/e=518.2 (M+1).

WORKUP

后处理

  1. customPrepared