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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1431302Generated: November 2, 2026

2-(Methylthio)benzeneboronic acid → 4-Chloro-5,7-difluoro-3-methyl-2-(2-(methylthio)phenyl)quinoline

https://huagongshe.com/reaction/1431302

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methylthio)benzeneboronic acidHCID 2773543—
Reactant2,4-Dichloro-5,7-difluoro-3-methylquinolineHCID 59631040—
Product4-Chloro-5,7-difluoro-3-methyl-2-(2-(methylthio)phenyl)quinolineHCID 59631363—

Reaction Steps

Prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (550 mg, 2.22 mmol) and 2-(methylthio)phenylboronic acid to give 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylthio)phenyl)quinoline. Mass Spectrum (ESI) m/e=336.1 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08940724B2
Source datasetuspto-grants-2015_01
ORD IDord-e7fbcd7707154c2e9c1fd2faa8c949bf
Source noteuspto-grants-2015_01