HRID1431305
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline (110 mg, 0.37 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-dimorpholinopyridin-3-yl)-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 7.62 (1H, br. s.), 7.53 (1H, d), 7.37 (1H, br. s.), 6.69-6.84 (1H, m), 6.29 (1H, d, J=2.3 Hz), 3.90 (4H, t, J=4.3 Hz), 3.72-3.84 (4H, m), 3.36 (4H, br. s.), 3.18 (2H, br. s.), 2.91-3.06 (4H, m), 2.09 (3H, s), 1.47-1.90 (8H, m). Mass Spectrum (ESI) m/e=525.3 (M+1).
WORKUP
后处理
- customPrepared