HRID1431309
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline (70.0 mg, 0.190 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)-4-quinolinamine. 1H NMR (CDCl3) δ ppm 8.21 (1H, d, J=7.8 Hz), 7.84 (1H, d, J=11.7.0 Hz), 7.80 (1H, td, J=7.5, 1.4 Hz), 7.70 (1H, td, J=7.7, 1.4 Hz), 7.54 (1H, br. s.), 7.50 (1H, d, J=9.4), 7.41 (1H, d, J=7.4 Hz), 7.06 (1H, ddd, J=13.5, 8.6, 2.5 Hz), 6.52 (1H, br. s.), 3.84-4.03 (4H, m), 3.70-3.83 (4H, m), 3.32-3.56 (2H, m), 2.87-3.19 (9H, m), 1.92 (3H, s). Mass Spectrum (ESI) m/e=596.2 (M+1).
WORKUP
后处理
- customPrepared