HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-morpholinopyridin-3-amine → N-(5-bromo-2-morpholinopyridin-3-yl)-5,8-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-morpholinopyridin-3-amine | HCID 46737873 | — |
| Reactant | 4-Chloro-5,8-difluoro-3-methyl-2-(pyridin-2-yl)quinoline | HCID 59631123 | — |
| Product | N-(5-bromo-2-morpholinopyridin-3-yl)-5,8-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine | HCID 59631425 | — |
Reaction Steps
Prepared according to the acid catalyzed Procedure K, Method 2 using 4-chloro-5,8-difluoro-3-methyl-2-(pyridin-2-yl)quinoline (300 mg, 1.03 mmol) and 5-bromo-2-morpholinopyridin-3-amine to give N-(5-bromo-2-morpholinopyridin-3-yl)-5,8-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine. Mass Spectrum (ESI) m/e=512.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-352a29a37d0b4eb3bb0637a2899268a8 |
| Source note | uspto-grants-2015_01 |