HRID1431312
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to Procedure H using N-(5-bromo-2-morpholinopyridin-3-yl)-5,8-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine (40.0 mg, 0.131 mmol) and morpholine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-5,8-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (CDCl3) δ ppm 8.68 (1H, d, J=3.9 Hz), 8.00 (1H, d, J=7.8 Hz), 7.78-7.96 (2H, m), 7.63 (1H, d, J=2.3 Hz), 7.34-7.44 (1H, m), 7.28-7.34 (1H, m), 7.11 (1H, ddd, J=12.8, 8.7, 3.9 Hz), 6.47 (1H, d, J=2.3 Hz), 3.87-4.01 (4H, m), 3.76-3.87 (4H, m), 3.15-3.49 (4H, m), 2.98-3.13 (4H, m), 2.26 (3H, s). Mass Spectrum (ESI) m/e=519.2 (M+1).
WORKUP
后处理
- customPrepared