Diethyl ethylmalonate → HCID 67508324, compound

HRID 1431313Notes

Reaction equation

HRID 1431313 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].[CH2:10]([CH:12]([C:18](OCC)=[O:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:11]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:18]([CH:12]([CH2:10][CH3:11])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:19])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

3

Reactant 2

HCID 8610Diethyl ethylmalonateHCID 965953,5-Difluoroaniline

Product 1

HCID 67508324HCID 67508324, compound

Procedure

Prepared according to Procedure A using 3,5-difluoroaniline (5.60 g, 43.4 mmol) and diethyl 2-ethylmalonate to give ethyl 2-(3,5-difluorophenylcarbamoyl)butanoate. Mass Spectrum (ESI) m/e=272.0 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2799762d60ba462abac4eef250d54b83
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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