HRID1431314
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to Procedure H using 4-chloro-3-ethyl-5,7-difluoro-2-(pyridin-2-yl)quinoline (40.0 mg, 0.131 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-3-ethyl-5,7-difluoro-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (CDCl3) δ ppm 8.70 (1H, td, J=2.4, 1.0 Hz), 7.79-8.00 (2H, m), 7.53-7.66 (2H, m), 7.45 (1H, d, J=6.3 Hz), 7.40 (1H, ddd, J=7.3, 4.8, 1.6 Hz), 6.98 (1H, ddd, J=12.8, 8.7, 2.6 Hz), 6.43 (1H, d, J=2.3 Hz), 3.87-4.07 (4H, m), 3.73-3.82 (4H, m), 3.15-3.35 (4H, m), 2.93-3.03 (4H, m), 2.70 (2H, br. s.), 0.98 (3H, t, J=7.5 Hz). Mass Spectrum (ESI) m/e=533.2 (M+1).
WORKUP
后处理
- customPrepared