HRID1431316
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Prepared according to Procedure H using 4-chloro-5,7-difluoro-2-(6-methoxypyridin-2-yl)-3-methylquinoline (40.0 mg, 0.125 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-5,7-difluoro-2-(6-methoxy-2-pyridinyl)-3-methyl-4-quinolinamine. 1H NMR (CDCl3) δ ppm 7.78-7.87 (1H, m), 7.77 (1H, dd,), 7.61-7.68 (2H, m), 7.56 (1H, dd, J=7.2, 0.8 Hz), 6.98-7.09 (1H, m), 6.86 (1H, dd, J=8.2, 0.8 Hz), 6.45 (1H, d, J=2.5 Hz), 3.93 (3H, s), 3.86-4.01 (4H, m), 3.71-3.83 (4H, m), 3.09-3.53 (4H, m), 3.02-3.08 (4H, m), 2.26 (3H, s). Mass Spectrum (ESI) m/e=549.3 (M+1).
WORKUP
后处理
- customPrepared