2,5-Dimorpholinopyridin-3-amine → 1-(4-((2,5-Di-4-morpholinyl-3-pyridinyl)-amino)-5,7-difluoro-3-methyl-2-quinolinyl)-2-piperidinone

Participants

Reaction Steps

Prepared according to Procedure H using 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one (35.0 mg, 0.113 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give 1-(4-((2,5-di-4-morpholinyl-3-pyridinyl)-amino)-5,7-difluoro-3-methyl-2-quinolinyl)-2-piperidinone. 1H NMR (CDCl3) δ ppm 8.01 (1H, br. s.), 7.60 (1H, d, J=2.5 Hz), 7.47 (1H, d, J=9.8 Hz), 6.99 (1H, ddd, J=13.7, 8.6, 2.5 Hz), 6.51 (1H, br. s.), 4.33 (1H, br. s.), 3.83-4.01 (4H, m), 3.77-3.83 (4H, m), 3.48-3.59 (1H, m), 3.41 (2H, br. s.), 3.16 (4H, br. s,), 2.89-3.07 (2H, m), 2.50-2.61 (2H, m), 1.88-2.19 (7H, m). Mass Spectrum (ESI) m/e=539.2 (M+1).

Provenance & Evidence