Diethyl methylmalonate → HCID 59631204, compound

Participants

Reaction Steps

Prepared according to Procedure A using diethyl 2-methylmalonate (4.91 mL, 28.6 mmol), pyridine (3.1 mL) and 4-chloro-3-methoxyaniline (3.00 g, 19.04 mmol). The reaction mixture was heated for 5 days. The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes) to give ethyl 3-(4-chloro-3-methoxyphenylamino)-2-methyl-3-oxopropanoate. Mass Spectrum (ESI) m/e=286.1 (M+1).

Provenance & Evidence