2-(Tributylstannyl)pyridine → HCID 59631212, compound

HRID 1431354Notes

Reaction equation

HRID 1431354 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([Cl:14])[CH:8]=2)[N:3]=1.C([Sn](CCCC)(CCCC)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)CCC>C1(C)C=CC=CC=1>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([Cl:14])[CH:8]=2)[N:3]=[C:2]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[C:11]=1[CH3:12]

Participants

4

Reactant 2

HCID 6077842-(Tributylstannyl)pyridineHCID 59631449HCID 59631449, compound

Product 1

HCID 59631212HCID 59631212, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The dichloride was prepared according to Procedure E using 2,4,6-trichloro-7-methoxy-3-methylquinoline (0.69 g, 2.49 mmol), 2-(tributylstannyl)pyridine (1.01 mL, 2.74 mmol), palladium tetrakistriphenylphosphine (0.29 g, 0.25 mmol) in toluene (5.00 mL) to give 4,6-dichloro-7-methoxy-3-methyl-2-(pyridin-2-yl)quinoline as a white solid. Mass Spectrum (ESI) m/e=319.0 (M+1).

Sources & evidence

ORD record
ord-f32908827f7e4e92ad61762996016da1
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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