Dimethyl malonate → HCID 59631472, compound

HRID 1431366Notes

Reaction equation

HRID 1431366 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].[C:10](OC)(=[O:16])[CH2:11][C:12]([O:14][CH3:15])=[O:13]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:16])[CH2:11][C:12]([O:14][CH3:15])=[O:13])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

3

Reactant 2

HCID 7943Dimethyl malonateHCID 965953,5-Difluoroaniline

Product 1

HCID 59631472HCID 59631472, compound

Procedure

Prepared according to Procedure A using 3,5-difluoroaniline (5.00 g, 38.7 mmol) and dimethyl malonate to give methyl 3-(3,5-difluorophenylamino)-3-oxopropanoate. Mass Spectrum (ESI) m/e=230.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-733ca1b4fc2c49999eedf062946168fb
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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