2,5-Dimorpholinopyridin-3-amine → HCID 59631128, compound

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Reaction Steps

Prepared according to Procedure H using 4-chloro-5,7-difluoro-2-(pyridin-2-yl)-quinoline (40.0 mg, 0.145 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-5,7-difluoro-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (CDCl3) δ ppm 8.65 (1H, d, J=7.2 Hz), 8.62 (1H, dt, J=4.8, 0.8 Hz), 8.54 (1H, s), 8.46 (1H, d, J=17.8 Hz), 7.87 (1H, td, J=7.7, 2.0 Hz), 7.83 (1H, d, J=2.7 Hz), 7.69 (1H, d, J=2.7 Hz), 7.66 (1H, br. s.), 7.36 (1H, ddd, J=7.5, 4.7, 1.1 Hz), 7.02 (1H, ddd, J=14.1, 8.4, 2.5 Hz), 3.89 (4H, dd, J=5.7, 3.9 Hz), 3.80-3.87 (4H, m), 3.24 (4H, dd, J=5.7, 3.9 Hz), 3.03-3.17 (4H, m). Mass Spectrum (ESI) m/e=505.1 (M+1).

Provenance & Evidence