HRID1431421
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline (34.0 mg, 0.120 mmol) and 2,5-dimorpholinoaniline in toluene to give N-(2,5-di-4-morpholinylphenyl)-5,7-difluoro-3-methyl-2-(1-piperidinyl)-4-quinolinamine. 1H NMR (CDCl3) δ ppm 7.97 (1H, d, J=7.6 Hz), 7.08 (1H, d, J=8.6 Hz), 6.67-6.82 (1H, m), 6.45 (1H, d, J=9.6 Hz), 6.06 (1H, d, J=2.2 Hz), 3.88 (4H, t, J=4.3 Hz), 3.70-3.82 (4H, m), 3.36 (4H, br. s.), 2.96-3.24 (4H, m), 2.70-2.97 (4H, m), 2.11 (3H, s), 1.58-1.92 (7H, m). Mass Spectrum (ESI) m/e=524.3 (M+1).
WORKUP
后处理
- customEssentially prepared