2,5-Dimorpholinopyridin-3-amine → 1-(4-((2,5-di-4-morpholinyl-3-pyridinyl)amino)-5,7-difluoro-3-methyl-2-quinolinyl)-2(1H)-pyridinone

Participants

Reaction Steps

Essentially prepared according to Procedure H using 1-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)pyridin-2(1H)-one (50.0 mg, 0.140 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give 1-(4-((2,5-di-4-morpholinyl-3-pyridinyl)amino)-5,7-difluoro-3-methyl-2-quinolinyl)-2(1H)-pyridinone. 1H NMR (CDCl3) δ ppm 8.29 (1H, dd, J=4.8, 1.1 Hz), 7.80-7.88 (1H, m), 7.72 (1H, d, J=10.2 Hz), 7.62 (1H, d, J=2.5 Hz), 7.27-7.33 (1H, m), 7.14-7.23 (2H, m), 6.91 (1H, ddd, J=13.3, 8.9, 2.4), 6.35 (1H, d, J=2.2 Hz), 3.92 (4H, br. s.), 3.76-3.83 (4H, m), 3.12-3.46 (4H, m), 2.98-3.07 (4H, m), 2.15 (3H, s). Mass Spectrum (ESI) m/e=535.2 (M+1).

Provenance & Evidence