2-Piperidone → 1-(4-Chloro-3-ethyl-5,7-difluoroquinolin-2-yl)piperidin-2-one

HRID 1431425노트

반응식

HRID 1431425 반응식
Cl[C:2]1[C:11]([CH2:12][CH3:13])=[C:10]([Cl:14])[C:9]2[C:4](=[CH:5][C:6]([F:16])=[CH:7][C:8]=2[F:15])[N:3]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][C:18]1=[O:23]>>[Cl:14][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:16])=[CH:7][C:8]=2[F:15])[N:3]=[C:2]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][C:18]2=[O:23])[C:11]=1[CH2:12][CH3:13]

참가 물질

3

반응물 2

HCID 126652-PiperidoneHCID 596313812,4-Dichloro-5,7-difluoro-3-ethylquinoline

생성물 1

HCID 596311411-(4-Chloro-3-ethyl-5,7-difluoroquinolin-2-yl)piperidin-2-one

실험 절차

Prepared according to Procedure I using 2,4-dichloro-5,7-difluoro-3-ethylquinoline (400 mg, 1.50 mmol) and piperidin-2-one to give 1-(4-chloro-3-ethyl-5,7-difluoroquinolin-2-yl)piperidin-2-one. Mass Spectrum (ESI) m/e=325.1 (M+1).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3c426daff5354c50b12c6935fee039fe
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940724B2

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