Reaction Steps
Prepared according to Procedure H using 4-chloro-7-fluoro-3-isopropyl-2-(pyridin-2-yl)quinoline (45.0 mg, 0.150 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-7-fluoro-3-(1-methylethyl)-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (400 MHz, chloroform-d) δ ppm 8.73 (1H, ddd, J=4.8, 1.7, 0.9 Hz), 7.88 (1H, td, J=7.7, 1.9 Hz), 7.72-7.79 (2H, m), 7.67 (1H, dt, J=7.8, 1.0 Hz), 7.58 (1H, d, J=2.7 Hz), 7.39 (1H, ddd, J=7.4, 4.9, 1.2 Hz), 7.23 (1H, ddd, J=9.4, 8.0, 2.5 Hz), 7.13 (1H, s), 6.11 (1H, d, J=2.5 Hz), 3.83-4.04 (4H, m), 3.67-3.79 (4H, m), 3.49 (2H, ddd, J=12.0, 6.3, 2.6 Hz), 3.25-3.42 (1H, m), 2.97 (2H, ddd, J=11.9, 6.2, 2.6 Hz), 2.85 (4H, t, J=4.8 Hz), 1.52 (3H, d, J=7.2 Hz), 1.12 (3H, d, J=7.0 Hz). Mass Spectrum (ESI) m/e=529.3 (M+1).
