2,5-Dimorpholinopyridin-3-amine → HCID 59631492, compound

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Reaction Steps

Prepared according to Procedure H using 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)pyrrolidin-2-one (35.0 mg, 0.120 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give 1-(4-((2,5-di-4-morpholinyl-3-pyridinyl)-amino)-5,7-difluoro-3-methyl-2-quinolinyl)-2-pyrrolidinone. 1H NMR (400 MHz, chloroform-d) δ ppm 8.09 (1H, d, J=13.5 Hz), 7.65 (1H, d, J=2.7 Hz), 7.42 (1H, ddd, J=9.6, 2.5, 1.4 Hz), 6.97 (1H, ddd, J=13.7, 8.6, 2.5 Hz), 6.62 (1H, d, J=2.5 Hz), 4.51 (1H, br. s.), 3.92 (4H, br. s.), 3.68-3.86 (4H, m), 3.22-3.52 (3H, m), 3.15-3.22 (4H, m), 3.02 (2H, br. s.), 2.62 (2H, t, J=7.8 Hz), 2.19-2.37 (2H, m), 2.03 (3H, s). Mass Spectrum (ESI) m/e=525.3 (M+1).

Provenance & Evidence