反应详情

Prepared according to Procedure H using 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-4-methylpiperazin-2-one (25.0 mg, 0.077 mmol) and 5-morpholinopyridin-3-amine in toluene to give 1-(5,7-difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-4-methyl-2-piperazinone. 1H NMR (400 MHz, chloroform-d) δ ppm 7.92 (1H, br. s.), 7.88 (1H, br. s.), 7.47 (1H, ddd, J=9.6, 2.5, 1.4 Hz), 7.23 (1H, d, J=14.9 Hz), 7.01 (1H, ddd, J=13.9, 8.6, 2.5 Hz), 6.53 (1H, t, J=2.1 Hz), 4.41 (1H, ddd, J=11.8, 5.2, 5.1 Hz), 3.75-3.89 (4H, m), 3.53-3.67 (1H, m), 3.29-3.43 (1H, m), 3.11-3.27 (5H, m), 2.82-2.96 (2H, m), 2.44 (3H, s), 1.95 (3H, s). Mass Spectrum (ESI) m/e=326.0 (M+1).

1. customPrepared