5-Morpholinopyridin-3-amine → HCID 59631522, compound

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Reaction Steps

Prepared according to Procedure H using 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-1-methylpiperazin-2-one (31.0 mg, 0.095 mmol) and 5-morpholinopyridin-3-amine in toluene to give 4-(5,7-difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-1-methyl-2-piperazinone. 1H NMR (400 MHz, chloroform-d) δ ppm 7.95 (1H, br. s.), 7.71 (1H, br. s.), 7.31 (1H, ddd, J=9.8, 2.6, 1.3 Hz), 6.94 (1H, d, J=13.1 Hz), 6.83 (1H, ddd, J=13.9, 8.6, 2.5 Hz), 6.60 (1H, s), 4.07 (2H, s), 3.84-3.91 (4H, m), 3.67 (2H, t, J=5.4 Hz), 3.53 (2H, t, J=5.4 Hz), 3.13-3.21 (4H, m), 3.03 (3H, s), 2.08 (3H, s). Mass Spectrum (ESI) m/e=469.3 (M+1).

Provenance & Evidence