5-Morpholinopyridin-3-amine → 1-(5,7-Difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-2-pyrrolidinone

Participants

Reaction Steps

Prepared according to Procedure H using 1-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)pyrrolidin-2-one (44.0 mg, 0.130 mmol) and 5-morpholinopyridin-3-amine in toluene to give 1-(5,7-difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-2-pyrrolidinone. 1H NMR (400 MHz, chloroform-d) δ ppm 7.93 (2H, dd, J=4.3, 2.3 Hz), 7.43 (1H, ddd, J=9.5, 2.5, 1.3 Hz), 7.36 (1H, d, J=14.5 Hz), 6.99 (1H, ddd, J=13.9, 8.6, 2.5 Hz), 6.64 (1H, t, J=2.2 Hz), 4.16 (2H, br. s.), 3.77-3.89 (4H, m), 3.20-3.30 (4H, m), 2.60 (2H, t, J=7.9 Hz), 2.27 (2H, qd, J=7.5, 7.3 Hz), 2.01 (3H, s). Mass Spectrum (ESI) m/e=440.2 (M+1).

Provenance & Evidence