反应详情

Prepared according to Procedure H using 1-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)pyrrolidin-2-one (44.0 mg, 0.130 mmol) and 5-morpholinopyridin-3-amine in toluene to give 1-(5,7-difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-2-pyrrolidinone. 1H NMR (400 MHz, MeOH) δ ppm 7.90 (1H, br. s.), 7.52-7.62 (1H, m), 7.49 (1H, ddd, J=9.6, 1.8, 1.7 Hz), 6.98-7.11 (2H, m), 3.81-3.87 (4H, m), 3.70 (2H, t, J=7.2 Hz), 3.26-3.30 (4H, m), 2.57 (2H, t, J=6.6 Hz), 2.13 (3H, s), 2.08 (2H, quin, J=6.9 Hz). Mass Spectrum (ESI) m/e=458.2 (M+1).

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