Potassium Carbonate → HCID 59631278, compound

Participants

Reaction Steps

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.5 g, 2.02 mmol), 3,4-dimethylphenylboronic acid (0.333 g, 2.22 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol), potassium carbonate (0.557 g, 4.03 mmol) in toluene (4 mL) at 100° C. for 48 h to give 4-chloro-2-(3,4-dimethylphenyl)-5,7-difluoro-3-methylquinoline as a white solid. Mass Spectrum (ESI) m/e=318.1 (M+1).

Provenance & Evidence