Potassium Carbonate → HCID 59631032, compound

Participants

Reaction Steps

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.50 g, 2.02 mmol), 1-methyl-1H-indazol-4-ylboronic acid (0.53 g, 3.02 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol), potassium carbonate (0.56 g, 4.03 mmol) in toluene (4 mL) at 100° C. for 17 h to give 4-chloro-5,7-difluoro-3-methyl-2-(1-methyl-1H-indazol-4-yl)quinoline as a yellow solid. Mass Spectrum (ESI) m/e=344.0 (M+1).

Provenance & Evidence