4-Methyl-2-(tributylstannyl)pyridine → 4-Chloro-7-fluoro-3-isopropyl-2-(4-methylpyridin-2-yl)quinoline

Participants

Reaction Steps

The Stille coupled product was prepared according to Procedure E using 2,4-dichloro-7-fluoro-3-isopropylquinoline (0.3 g, 1.162 mmol), 4-methyl-2-(tributylstannyl)pyridine (0.489 g, 1.28 mmol) and palladium tetrakistriphenylphosphine (0.134 g, 0.12 mmol) in toluene (2.3 mL) at 100° C. for 6.5 days to give 4-chloro-7-fluoro-3-isopropyl-2-(4-methylpyridin-2-yl)quinoline as a white solid. Mass Spectrum (ESI) m/e=315.1 (M+1).

Provenance & Evidence