4-Methyl-2-(tributylstannyl)pyridine → 4-Chloro-7-fluoro-3-methyl-2-(4-methylpyridin-2-yl)quinoline

Participants

Reaction Steps

The Stille coupled product was prepared according to Procedure E using 2,4-dichloro-7-fluoro-3-methylquinoline (0.109 g, 0.47 mmol), 4-methyl-2-(tributylstannyl)pyridine (0.199 g, 0.52 mmol), palladium tetrakistriphenylphosphine (0.055 g, 0.047 mmol) in toluene (2 mL) to give 4-chloro-7-fluoro-3-methyl-2-(4-methylpyridin-2-yl)quinoline as a white solid. Mass Spectrum (ESI) m/e=287.0 (M+1).

Provenance & Evidence