2-(Tributylstannyl)pyrazine → HCID 59631144, compound

HRID 1431486Notes

Reaction equation

HRID 1431486 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.C([Sn](CCCC)(CCCC)[C:21]1[CH:26]=[N:25][CH:24]=[CH:23][N:22]=1)CCC>C1(C)C=CC=CC=1>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:21]2[CH:26]=[N:25][CH:24]=[CH:23][N:22]=2)[C:11]=1[CH3:12]

Participants

4

Reactant 2

HCID 27373162-(Tributylstannyl)pyrazineHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 59631144HCID 59631144, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The Stille coupled product was prepared according to Procedure E using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.5 g, 2.02 mmol), 2-(tributylstannyl)-pyrazine (0.818 g, 2.22 mmol), palladium tetrakistriphenylphosphine (0.233 g, 0.20 mmol) in toluene (4 mL) to give 4-chloro-5,7-difluoro-3-methyl-2-(pyrazin-2-yl)quinoline as a white solid. Mass Spectrum (ESI) m/e=292.0 (M+1).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-aa1a2896925449f9af921f9369822a0a
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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