Potassium Carbonate → 2-(2,4-Bis(trifluoromethyl)phenyl)-4-chloro-5,7-difluoro-3-methylquinoline

Participants

Reaction Steps

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.50 g, 2.02 mmol), 2,4-bis(trifluoromethyl)phenylboronic acid (0.572 g, 2.22 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol), potassium carbonate (0.56 g, 4.03 mmol) in toluene (4 mL) at 100° C. for 22 h to give 2-(2,4-bis(trifluoromethyl)phenyl)-4-chloro-5,7-difluoro-3-methylquinoline as a crystalline solid. Mass Spectrum (ESI) m/e=426.0 (M+1).

Provenance & Evidence