Potassium Carbonate → HCID 59631167, compound

Participants

Reaction Steps

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.50 g, 2.02 mmol), 3-chloropyridine-5-boronic acid (0.381 g, 2.42 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol), potassium carbonate (0.56 g, 4.03 mmol) in toluene (4 mL) at 100° C. for 19.5 h to give 4-chloro-2-(5-chloropyridin-3-yl)-5,7-difluoro-3-methylquinoline as an off white solid. Mass Spectrum (ESI) m/e=325.0 (M+1).

Provenance & Evidence