Potassium Carbonate → HCID 66632601, compound

Participants

Reaction Steps

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.35 g, 1.4 mmol), 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.50 g, 2.12 mmol), palladium tetrakistriphenylphosphine (0.16 g, 0.14 mmol), potassium carbonate (0.49 g, 4.23 mmol) in toluene (2.8 mL) at 100° C. for 17.6 h to give 4-chloro-5,7-difluoro-2-(5-methoxypyridin-3-yl)-3-methylquinoline as a white solid. Mass Spectrum (ESI) m/e=321.0 (M+1).

Provenance & Evidence