Potassium Carbonate → HCID 59631339, compound

Participants

Reaction Steps

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.5 g, 2.0 mmol), 2-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.666 g, 2.42 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol), potassium carbonate (0.84 g, 6.1 mmol) in toluene (4.0 mL) at 100° C. for 18.3 h to give 4-chloro-2-(6-(cyclopropylmethoxy)pyridin-3-yl)-5,7-difluoro-3-methylquinoline as a light yellow solid. Mass Spectrum (ESI) m/e=361.1 (M+1).

Provenance & Evidence