5-Morpholinopyridin-3-amine → 1-(5,7-Difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-2-pyrrolidinone

Participants

Reaction Steps

Essentially prepared according to Procedure H using 1-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one (75.0 mg, 0.21 mmol) and 5-morpholinopyridin-3-amine in toluene to give 1-(5,7-difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-2-pyrrolidinone. 1H NMR (400 MHz, CDCl3) δ ppm 7.90 (1H, d, J=2.5 Hz), 7.86 (1H, d, J=2.3 Hz), 7.46 (1H, ddd, J=9.6, 2.5, 1.4 Hz), 7.24 (1H, d, J=14.1 Hz), 6.99 (1H, ddd, J=13.9, 8.6, 2.5 Hz), 6.54 (1H, t, J=2.4 Hz), 4.22-4.33 (1H, m), 3.82 (4H, t, J=4.8 Hz), 3.48-3.58 (1H, m), 3.13-3.28 (4H, m), 2.50-2.58 (2H, m), 2.07-2.14 (1H, m), 1.95-2.04 (3H, m), 1.94 (3H, s).

Provenance & Evidence