5-Morpholinopyridin-3-amine → HCID 57449778, compound

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)-1-ethylpiperazin-2-one (31.0 mg, 0.081 mmol) and 5-morpholinopyridin-3-amine in toluene to give 4-(5,7-difluoro-3-methyl-4-((5-(4-morpholinyl)-3-pyridinyl)amino)-2-quinolinyl)-1-ethyl-2-piperazinone. 1H NMR (400 MHz, CDCl3) δ ppm 7.85 (1H, d, J=2.2 Hz), 7.75 (1H, d, J=2.0 Hz), 7.57 (1H, d, J=6.7 Hz), 7.28-7.36 (1H, m), 6.93 (1H, s), 6.83 (1H, ddd, J=13.3, 8.7, 2.5 Hz), 4.11 (2H, s), 3.81-3.92 (4H, m), 3.72 (2H, t, J=5.3 Hz), 3.43-3.56 (4H, m), 3.19-3.30 (4H, m), 2.20 (3H, s), 1.18 (3H, t, J=7.2 Hz). Mass Spectrum (ESI) m/e=483.3 (M+1).

Provenance & Evidence