Sodium hydride → HCID 59631129, compound

Participants

Reaction Steps

The 4-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)piperazin-2-one (70 mg, 0.200 mmol) was dissolved in THF (2.0 mL). To the solution was added sodium hydride (24.0 mg, 0.98 mmol) (60% dispersion) followed by addition of 1-iodopropane (230 μL, 2.40 mmol). The reaction was stirred overnight. The reaction was quenched with water and the mixture was extracted with EtOAc (2×50 mL). The combined organic layers were washed with brine (1×25 mL) and dried over magnesium sulfate. The crude product was purified by medium pressure chromatography (silica gel, 0 to 80% EtOAc:hexanes) to give 4-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)-1-propylpiperazin-2-one. Mass Spectrum (ESI) m/e=400.1 (M+1).

Provenance & Evidence