Toluene → HCID 59631495, compound

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-(4-bromo-5,7-difluoro-3-methylquinolin-2-yl)-1-ethylpiperazin-2-one (35.0 mg, 0.088 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give 4-(4-(2,5-dimorpholinopyridin-3-ylamino)-5,7-difluoro-3-methylquinolin-2-yl)-1-propylpiperazin-2-one. 1H NMR (TFA salt) (400 MHz, CDCl3) δ ppm 7.79 (1H, d, J=2.5 Hz), 7.72 (1H, d, J=10.8 Hz), 7.40 (1H, ddd, J=9.7, 2.4, 1.2 Hz), 6.88 (1H, ddd, J=13.5, 8.6, 2.5 Hz), 6.47 (1H, d, J=2.7 Hz), 5.94 (3H, br. s.), 3.96-4.35 (3H, m), 3.87-3.95 (4H, m), 3.77-3.86 (4H, m), 3.54-3.76 (2H, m), 3.12-3.54 (7H, m), 2.99-3.13 (4H, m), 2.14 (3H, s), 1.63 (2H, sxt, J=7.5 Hz), 0.93 (3H, t, J=7.4 Hz). Mass Spectrum (ESI) m/e=582.2 (M+1).

Provenance & Evidence